Solving Foam Challenges in Microbial Fermentation: Chemi Tech's Specialized Defoamer Precision Control Solution

Excessive foam generation is a common and challenging issue in microbial fermentation processes. Persistent foam not only reduces the effective volume of the fermenter but can also cause overflows, leading to product loss and environmental concerns. More critically, it impedes oxygen transfer and disrupts normal microbial metabolism, ultimately compromising fermentation efficiency and product yield. Traditional defoaming methods often face limitations such as high dosage requirements, inconsistent performance, and potential adverse effects on cell growth or downstream processing.

Addressing these core challenges, Chemi Tech has dedicated itself to developing a series of high-performance specialized defoamers for microbial fermentation. Our solution goes beyond merely eliminating foam after it forms; it focuses on precise prediction and control throughout the fermentation cycle. The core lies in a unique multi-component synergistic system that rapidly reduces the surface tension of foam lamellae, causing quick bubble collapse, and maintains long-lasting antifoam performance within the fermentation broth to prevent foam from re-accumulating.

Our professional service involves the following concrete steps: First, our technical team conducts an in-depth analysis of the client's fermentation process, microbial strain characteristics, medium composition, and root causes of foaming. Subsequently, based on the analysis, we select or customize the most compatible product type from Chemi Tech's range of defoamers, ensuring both high efficiency and process safety. Next, we provide detailed recommendations for addition points, methods, and dosages, typically suggesting fed-batch or drip addition for precise and economical foam control. Finally, we offer comprehensive technical support to help clients optimize application protocols for stable production.

In an application at an amino acid manufacturing facility, persistent foam during mid-to-late fermentation stages, caused by metabolite accumulation, was problematic. Generic defoamers were ineffective and affected yield. After engagement by Chemi Tech's technical team, analysis of the broth properties led to the recommendation of a specific silicone-nonsilicone compound defoamer, along with an optimized addition strategy. Post-implementation, the fermenter working volume increased by 15%, effectively preventing overflow risks. Product yield showed stable improvement, with no negative impact on cell growth or downstream recovery. The client expressed strong satisfaction with the consistent production results.

Choosing Chemi Tech means opting for reliable process assurance. We are committed to helping you overcome foam obstacles in fermentation through our professional defoaming solutions, enhancing your production efficiency and economic returns.