Excessive foam is a common challenge in microbial fermentation, lowering production efficiency, causing product loss and even equipment failure. The market urgently needs efficient, stable defoamers that defoam quickly and suppress foam long-term in complex fermentation environments, without harming strain activity or final product quality.
Targeting these pain points, Chemi Tech has developed a defoamer series dedicated to microbial fermentation. Using special organosilicon compounds and emulsification technology, the product has extremely low surface tension, disperses rapidly in the broth, destroys foam structures and prevents regeneration. It resists high temperature, acids and alkalis, suits a wide range of fermentation conditions, and is non-toxic to microorganisms without interfering with metabolic pathways.
The solution follows these steps: first, determine the foaming characteristics of the fermentation system and the defoamer dosage through small-scale tests; second, add the defoamer in the early or middle stage of fermentation by fed-batch or one-shot dosing, typically at 0.01%–0.1%; finally, monitor foam levels in real time and adjust process parameters to optimize performance.
A biotechnology company faced runaway foam in amino acid fermentation, cutting capacity by 15%. After adopting the Chemi Tech defoamer with an optimized dosing strategy, foam dropped by 90%, fermenter fill factor rose by 12%, and product purity improved. The customer has used this solution stably for more than a year.
Chemi Tech defoamers have been applied successfully in multiple fermentation projects, including enzymes and organic acids, helping customers achieve stable, efficient fermentation. We provide technical support and customized services to ensure the defoaming plan matches each specific process perfectly.